Personally I have had the RS250 in the past (I have had the 150B model for 2 years now) and I have also listened to the 250A model at a friend’s.
Differences:
The 150B has more detailed sound and above all it offers a more natural and focused sound image (after all we are talking about a machine that costs twice as much).
Cons (but not essential):
The front display is much less detailed than the 250 models.
Without a shadow of a doubt you must use quality XLR cables to make it express itself at its best!
Personally I would really like to switch to the 130 + 160 model but I would have to donate a part of my body to be able to buy them!!