I have had this happen twice now in the month or so I’ve owned my RS250.
I’ve only had this happen when using Roon, as I use that 99% of the time. I occasionally use RoseTube, but have not used it enough to have the problem occur.
I use the RS250 RCA outputs set at a fixed 2v output level into my integrated amp. If I turn the amp volume WAY up I can hear music very quietly.
Rebooting the RS250 with the power button has always solved the issue, so far.
Hopefully this is a software glitch that can be resolved.